Sensitivity of commercial Anti-SARS-CoV-2 serological assays in a high-prevalence setting

  1. Lisa Müller
  2. Philipp N. Ostermann
  3. Andreas Walker
  4. Tobias Wienemann
  5. Alexander Mertens
  6. Ortwin Adams
  7. Marcel Andree
  8. Sandra Hauka
  9. Nadine Lübke
  10. Verena Keitel
  11. Ingo Drexler
  12. Veronica Di Cristanziano
  13. Derik Franz Hermsen
  14. Rolf Kaiser
  15. Friedrich Boege
  16. Florian Klein
  17. Heiner Schaal
  18. Jörg Timm
  19. Tina Senff
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Abstract

We analysed SARS-CoV-2 specific antibody responses in 42 social and working contacts of a super-spreader from the Heinsberg area in Germany. Consistent with a high-prevalence setting 26 individuals had SARS-CoV-2 antibodies determined by in-house neutralisation testing. These results were compared with four commercial assays, suggesting limited sensitivity of the assays in such a high-prevalence setting. Although SARS-CoV-2 nucleocapsid-restricted tests showed a better sensitivity, spike-based assays had a stronger correlation with neutralisation capacity.

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