A Living Organoid Biobank of Crohn’s Disease Patients Reveals Distinct Clinical Correlates of Molecular Disease Subtypes

  1. Harrison M. Penrose
  2. Saptarshi Sinha
  3. Courtney Tindle
  4. Kameron Zablan
  5. Helen N. Le
  6. Jennifer Neill
  7. Pradipta Ghosh
  8. Brigid S. Boland
0 evaluations Published on
Read the full article Related papers
This article on Sciety

Abstract

GRAPHICAL ABSTRACT

<fig id="ufig1" position="float" fig-type="figure" orientation="portrait"> <graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="25325058v2_ufig1" position="float" orientation="portrait"/> </fig>

In this prospective study, Penrose et al. evaluate a living biobank of genotyped and phenotyped patient-derived organoids (PDOs) as predictive tools in Crohn’s disease, demonstrating their ability to faithfully capture past, present, and future disease behavior, and advancing PDO-informed precision medicine beyond oncology and into complex inflammatory disorders.

Related articles

Related articles are currently not available for this article.