Cocaine withdrawal enhances subthalamic reward sensitivity

  1. Maya Williams
  2. Cassandre Vielle
  3. Jeanne-Laure de Peretti
  4. Alix Tiran-Cappello
  5. Christophe Melon
  6. Ali Awada
  7. Yann Pelloux
  8. Nicolas Maurice
  9. Christelle Baunez
  10. Mickaël Degoulet
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Abstract

High-frequency stimulation of the subthalamic nucleus (STN) has shown therapeutic potential in preclinical models of addiction. However, its rewarding properties remain unclear. Here, we show that cocaine withdrawal enhances STN intracranial self-stimulation, revealing a reward-based mechanism that may contribute to the beneficial effects of STN deep brain stimulation in addiction and related neuropsychiatric disorders.

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