Cardiac Troponin T Elevation Predicts Mortality in Hospitalized COVID-19 Patients

Objective

To evaluate if cardiac troponin values predict poor outcomes in COVID-19 patients across the range of patients of different sex and age.

Methods

We examined high-sensitivity cardiac troponin T (hs-cTnT) levels in 1,050 severely ill hospitalized COVID-19 patients who had hs-cTnT data available and participated in the Expanded Access Program for convalescent plasma study during the first wave (April-August 2020) of the COVID-19 pandemic.

Results

We observed a continuous relationship between hs-cTnT levels and mortality in hospitalized males and females with COVID-19. This finding was present regardless of sex or age.

Conclusion

These data indicate the prognostic ability of hs-cTnT to predict mortality in hospitalized COVID-19 patients across all relevant patient groups.

Clinical Trials registration number

NCT04338360

Clinical Perspective

• This study evaluated the prognostic value of elevated hs-cTnT in patients hospitalized with COVID-19 who received convalescent plasma.

• There was a continuous relationship between elevated hs-cTnT values and mortality in both males and females hospitalized for COVID-19.

• The magnitude of the prognostic value of elevated hs-cTnT varied by sex and age, suggesting that these covariates are important to consider in this population.