Urinary Multidrug-Resistant Klebsiella pneumoniae: Essential-Oil Countermeasures in a One Health Case Report

Carbapenem-resistant Klebsiella pneumoniae (CR‑Kp) is eroding therapeutic options for urinary-tract infections. We isolated a multidrug-resistant strain from the urine of a chronically bacteriuric patient and confirmed its identity by Vitek-2 and MALDI-TOF MS. Initial disk-diffusion profiling against 48 antibiotics revealed susceptibility to only five agents. One month later, repeat testing showed that tetracycline alone remained active, highlighting the strain’s rapidly evolving resistome. Given the scarcity of drug options, we performed an “aromatogram” with six pure essential oils and two commercial phytotherapeutic blends. Biomicin Forte® produced a 30 mm bactericidal halo, while thyme, tea-tree, laurel and palmarosa oils yielded clear inhibition zones of 11–22 mm. These in-vitro data demonstrate that carefully selected plant-derived products can target CR-Kp where conventional antibiotics fail. Integrating aromatogram results into One-Health stewardship plans may therefore help preserve last-line antibiotics and provide adjunctive options for persistent urinary infections.