Myricetin induces cell cycle arrest and suppresses tumorigenesis in bladder cancer through the interaction of EGFR-Ras and Fas signaling pathways

Myricetin is a natural flavonol glycoside that is widely found in the fruits, bark and leaves of plant. Myricetin have been reported to possess a variety of biological activi-ties, such as antioxidant properties, anti-inflammatory effects, and antitumor activity. In this study, In this study, we demonstrated for that hyperoside inhibited the prolifer-ation of bladder cancer cells in vitro and in vivo. Moreover, hyperoside could not only induce cell cycle arrest, but also induce apoptosis in bladder cancer cells. Bioinformat-ics analysis showed that myricetin may act mainly through the EGFR-Ras and Fas sig-naling pathways. In vitro experiments showed that myricetin activated the EGFR-Ras and Fas signaling pathways, up-regulated the protein levels of EGFR, Ras and Fas. Then further activated the downstream proteins MAPK and Akt. Through the interac-tion of downstream signaling, it ultimately promotes its anticancer effects on bladder cancer cells. This study suggests that myricetin may be a promising therapeutic clinical candidate for bladder cancer.