Determination of oxidant-antioxidant levels in individuals vaccinated against COVID-19 before and after vaccination

In this study, the oxidative stress status of adults who received Pfizer/BioNTech and Sinovac vaccines was examined in order to evaluate the approach to antioxidant use in vaccination and pandemic processes. A total of 53 individuals who received Covıd-19 vaccine (BNT162b2 and CoronaVac) were included in the study. Antioxidant (CAT, GPx, total GSH, ARE, PON) and oxidant (MDA and MPO) levels of the samples were determined by applying manual procedures. When the effects of the two vaccines on antioxidant levels were compared, only the changes in PON levels were significantly different. When the time effect was analyzed for both vaccines, catalase, ARE, GPx levels decreased significantly after the first dose of vaccination. In addition, GPx levels showed significant differences between all times. When the time effect was evaluated for both vaccines, MPO levels were significantly different between the initial and 2nd vaccinations and between the 1st and 2nd vaccinations. Oxidative stress increases potential side effects after vaccination and can reduce the effectiveness of Covid-19 protection and treatment management, including the vaccine approach. Strengthening antioxidant capacity, and if necessary, antioxidant supplementation in risky individuals will contribute to increasing vaccination effectiveness and strengthening national and global immunity.