The Tasmania-London (TASLON) 3-step home-based video-polysomnography approach to detect iRBD in the community: protocol and preliminary results

Study Objective: Isolated rapid eye movement (REM) sleep behaviour disorder (iRBD) is an early manifestation of alpha-synuclein-related neurodegenerative diseases (NDD). There is an average delay in iRBD diagnosis of 9 years showing that we need easier methods of detection to improve access to specialist care and disease modifying clinical trials. We designed a 3-step approach to detect iRBD in a community of older adults (>50years) in Tasmania, Australia using home-based video-polysomnography (vPSG). Methods: The Tasmania-London (TASLON) iRBD detection protocol comprised 3 steps: participants completed an online iRBD screening question; those who screened positive were invited to undertake the TASLON iRBD Screening Interview by telephone; a sample then completed a home-based vPSG based on iRBD screening risk level. Results: A total of 2891 participants (mean [SD] age 64 [7.7] years; 26% male) without any known NDD were recruited from throughout Tasmania. 267 (9%; age 63[7.7] years; 45% male) were identified as having ‘probable’ RBD through positive online screening; 85 (32%) agreed to complete the clinical screening interview; 48 (56%) underwent home-based vPSG; and 21(44%; age 68[7] years; 48% male) were found to have iRBD. Conclusion: The TASLON 3-step approach is a feasible method of improving timely access to iRBD diagnoses in the community. It streamlines the path to vPSG by identifying those at highest risk of iRBD, thus improving access to diagnostic testing and clinical trial opportunities for those who otherwise may not have been identified.