In-Silico Design, Synthesis and Biological Evaluation of Ferulic acid derivatives as Novel Urease Inhibitors

Ferulic acid is a hydroxycinnamic acid and comes in category of phenolic compound. The plant species Gramineae and Ranunculaceae are the main sources of Ferulic acid, which is also known as 3-(4-Hydroxy-3-methoxyphenyl) acrylic acid. Ferulic acid has been reported antimicrobial, antioxidant, antidiabetic, cardioprotective, anticancer and anti-inflammation activity. Current research study focused on synthetic preparation of Ferulic acid derivatives and their molecular docking analysis. The result demonstrated tremendous result when compared with standard drug Thiourea taking PDB id (4UBP); all the Ferulic derivatives show’s high docking result ranging (-4.899 to -5.976) when compared to Thiourea whose docking result lies (-3.429). These result of Ferulic derivative [FA1-FA5] exhibit a more potent and irreversible enzyme inhibitor of the urease enzyme for treatment of different urinary tract infections in future.