Intravascular Large B-cell Lymphoma Presenting as Migraine with Aura: Case Report

Introduction Intravascular large B-cell lymphoma is a rare, fatal, aggressive lymphoma which is characterized by proliferation of clonal lymphocytes within the lumen of small, medium, and large vessels. Diagnosis is challenging given non-specific initial presentation. Case report We report a case of intravascular large B-cell lymphoma in a 62-year-old female who presented to clinic with symptoms of ocular migraine. MRI brain showed signal abnormalities in the splenium of the corpus callosum, right frontal and bilateral parietal lobes. She ultimately underwent brain biopsy and was found to have intravascular large B-cell lymphoma and was transferred to specialist oncological center to be started on R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy. She passed away 7 months after the initial outpatient visit. Conclusion This case report shows another presentation of this rare and fatal disease and hopes that the reader will keep this differential in mind when searching for a diagnosis.