The Relationship between Sarcopenia and the Systemic Immune-Inflammation Index in a Patient Age 80 and Above Short Title: Sarcopenia and Systemic Inflammatory Index

Objective Sarcopenia, defined as the loss of muscle mass and function associated with aging, significantly impacts the quality of life of elderly individuals. This study investigated the relationship between the risk of sarcopenia and the systemic immune-inflammation index (SII) in elderly individuals aged 80 years and above. Methods This study involved 214 patients aged 80 years and above who presented at the Rize Recep Tayyip Erdoğan University Training and Research Hospital. The risk of sarcopenia was assessed via the Strength, Assistance with Walking, Rising from a Chair, Climbing Stairs, and Falls test, and laboratory tests were used to analyze inflammation levels. Results The findings of this study revealed significant differences in inflammation parameters among patients at risk of sarcopenia. SII and C-reactive protein/albumin ratios are particularly associated with the risk of sarcopenia. Age, sex, the serum ALB level, the neutrophil count, the platelet count, and the SII emerged as independent predictors of the risk of sarcopenia. Receiver operating characteristic analysis demonstrated that the SII may serve as a predictor of the risk of sarcopenia. Conclusion The integration of biomarkers such as the SII in the detection of sarcopenia in elderly individuals may play an important role in early diagnosis and treatment management. These findings further our understanding of the relationship between sarcopenia and inflammation while supporting the potential use of the SII in clinical practice. Trial Registration: This is not a clinical trial.